Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Organic Chemistry >  Heterocyclic Compounds >  7-Azaindole

7-Azaindole

Basic information Safety Supplier Related

7-Azaindole Basic information

Product Name:
7-Azaindole
Synonyms:
  • 1,7-Diaza-1H-indene
  • 7-Aza-7H-indole
  • 7-Aza-1-pyrindine
  • 7H-Pyrrolo[2,3-b]pyridine
  • Pyrrolo(2,3-b)pyridine
  • 7-AZAINDOLE CRYSTALLINE
  • 7-AZAINDOLE 98%
  • 7-Azaindole99%
CAS:
271-63-6
MF:
C7H6N2
MW:
118.14
EINECS:
205-981-0
Product Categories:
  • blocks
  • IndolesOxindoles
  • Heterocycles
  • Heterocycles series
  • Indole Derivatives
  • Pharmaceutical intermediate
  • Indole
  • Heterocyclic Compounds
  • Indole Series
  • Aromatics
  • Heterocycle-Indole series
  • Heterocycle-Pyridine series
  • buildingblock
  • Halogenated Heterocycles ,Thiazoles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
271-63-6.mol
More
Less

7-Azaindole Chemical Properties

Melting point:
105-107 °C (lit.)
Boiling point:
270 °C (753.1004 mmHg)
Density 
1.1151 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
270°C
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol
pka
7.69±0.20(Predicted)
form 
Powder
color 
White to off-white
BRN 
109667
InChIKey
MVXVYAKCVDQRLW-UHFFFAOYSA-N
CAS DataBase Reference
271-63-6(CAS DataBase Reference)
NIST Chemistry Reference
1H-Pyrrolo[2,3-b]pyridine(271-63-6)
EPA Substance Registry System
1H-Pyrrolo[2,3-b]pyridine (271-63-6)
More
Less

Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36-41-37/38-22
Safety Statements 
39-26-36/37/39
WGK Germany 
3
RTECS 
UY8710000
HazardClass 
IRRITANT
HS Code 
29339990

MSDS

More
Less

7-Azaindole Usage And Synthesis

Chemical Properties

Brown-Cyrstalline Solid

Uses

7-Azaindole is imidazolinone derivatives as CGRP receptor antagonists used in the treatment.
A heterocyclic molecule that can be utilized as a pharmaceutical building block.
Starting material in a recent synthesis of azaserotonin.

Application

7-Azaindole is a heterocyclic organic compound, which is an organic synthesis intermediate and a pharmaceutical intermediate. It is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, p38 kinase inhibitors, thrombin inhibitors, etc.

Preparation

Synthesis of 7-azaindole: in a single-necked flask, add 2.0 g of 2-amino-3-methylpyridine and 2.5 g of N-Methylformanilide into 40 mL of dichloromethane, and add 3.15 g of PCl with stirring under an ice-water bath. After 4 hours of reaction, the reaction system was slowly poured into 40 mL of ammonia water, and the insoluble matter was removed by suction filtration. The organic layer was separated, washed twice with water, dried over anhydrous sodium sulfate, and evaporated to dryness to obtain 2.91 g of 7-azaindole as a pale yellow solid, with a yield of 70%.

Definition

ChEBI: 1H-pyrrolo[2,3-b]pyridine is a pyrrolopyridine.

Purification Methods

Recrystallise it repeatedly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the picrate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]

7-Azaindole Supplier

Terma Medicare India Pvt Ltd Gold
Tel
021-52530655 18930806002
Email
yuli@semsstar.com
ABACHEM Gold
Tel
13816002712
Email
liu_wj@abachem.com
Shanghai Arbor Chemical Co., Ltd. Gold
Tel
021-021-60451683 15021268886
Email
sales@arborchemical.com
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. Gold
Tel
025-66099280 17798518460
Email
cfzhang@aikonchem.com
Jinan Dexinjia Biological Technology Co., Ltd Gold
Tel
0531-8237-5880 15098789112
Email
2710825968@qq.com