Lurosetron Chemical Properties

Boiling point:

650.1±55.0 °C(Predicted)

Density 

1.40±0.1 g/cm3(Predicted)

pka

14.01±0.10(Predicted)

Lurosetron Usage And Synthesis

Uses

Lurosetron (GR-87442) is a 6-fluoro analogue of Alosetron (HY-70050A). Lurosetron is a serotonin 5-HT3 receptor antagonist. Lurosetron inhibits recombinant (rbt) CYP1A2, with an IC50 of 0.1 μM. Lurosetron also inhibits other CYP isoforms, including rbtCYP2C9 and rbtCYP3A4 with IC50s ranging between 3.5 μM and 16 μM.[1].

IC 50

5-HT₃ Receptor

References

[1] Somers GI, et al. The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: a comparison of in vitro and in vivo metabolism and in vitro enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes. Xenobiotica. 2007 Aug;37(8):832-54. DOI:10.1080/00498250701485575

Lurosetron(128486-54-4)Related Product Information

• 7-FLUORO-1H-INDOLE-3-CARBALDEHYDE
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• 1H-Indole-3-carboxamide(9CI)
• 7-Fluoroindole
• Lurosetron
• 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole
• 2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
• 3-CARBAMOYL-2-METHYLINDOLE
• N-(2-(1-METHYL-1H-PYRROL-2-YL)ETHYL)FORMAMIDE
• ALOSETRON
• 1-METHYL-4,5,6,7-TETRAHYDRO-1H-PYRROLO[3,2-C]PYRIDINE
• 2-METHYL-3-N,N-DIMETHYLAMINOMETHYLINDOLE
• 7-FLUORO-1H-INDOL-3-METHYLAMINE