6-Hydroxy-5-nitro-2-picoline Chemical Properties

Melting point:

225-226 C

Boiling point:

277.46°C (rough estimate)

Density 

1.4564 (rough estimate)

refractive index 

1.5100 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

8.47±0.10(Predicted)

color 

Light yellow to Brown to Dark green

CAS DataBase Reference

39745-39-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

37/39-26-36-39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29337900

MSDS

• Language:English Provider:ACROS

6-Hydroxy-5-nitro-2-picoline Usage And Synthesis

Chemical Properties

Yellow crystalline powder

Uses

2-Hydroxy-6-methyl-3-nitropyridine is a water soluble compound that has been used for the treatment of tuberculosis.

Synthesis

Synthesis of 2-hydroxy-3-nitro-6-methylpyridine: 2-amino-3-nitro-6-methylpyridine (10 g, 0.065 mol) was added to 100 mL of water, and concentrated sulfuric acid (12 mL) was added slowly under stirring and cooled to 0 °C in an ice bath. Sodium nitrite (6.9 g, 0.098 mol) was added in batches, and the reaction temperature was maintained at 0 °C for 4 h, followed by a 12 h standing time. A large amount of yellow precipitate precipitated during the reaction, the precipitate was collected by filtration under reduced pressure and dried under vacuum to give 7.7 g of yellow target product in 77% yield. The melting point of the product was 216.5-218.5 °C (water).

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 11
[2] Journal of the American Chemical Society, 1952, vol. 74, p. 3828,3830

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