Basic information Safety Supplier Related

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

Basic information Safety Supplier Related

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Basic information

Product Name:
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
Synonyms:
  • 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
  • 9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID
  • CDUVSQMTLOYKTR-ZHALLVOQSA-N
  • 13,14-dihydro-15-keto PGE1
  • 9,15-dioxo-11α-hydroxy-prostan-1-oic acid
  • U 21002
  • Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-
  • 15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056
CAS:
5094-14-4
MF:
C20H34O5
MW:
354.49
Mol File:
5094-14-4.mol
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13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Chemical Properties

Boiling point:
537.2±35.0 °C(Predicted)
Density 
1.072±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly), THF (Slightly)
form 
Oil
pka
4.77±0.10(Predicted)
color 
Dark Yellow
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13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Usage And Synthesis

Description

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM.

Uses

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.

Definition

ChEBI: 13,14-dihydro-15-oxoprostaglandin E1 is a prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. It has a role as a human xenobiotic metabolite. It is functionally related to a prostaglandin E1. It is a conjugate acid of a 13,14-dihydro-15-oxoprostaglandin E1(1-).

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