Basic information Safety Supplier Related

15(R)-PROSTAGLANDIN E1

Basic information Safety Supplier Related

15(R)-PROSTAGLANDIN E1 Basic information

Product Name:
15(R)-PROSTAGLANDIN E1
Synonyms:
  • 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTAN-1-OIC ACID
  • 13,14-DIHYDROPROSTAGLANDIN E1
  • PGE0
  • 13,14-Dihydroprostaglandinee1
  • 13,14-dihydro PGE1
  • 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoctyl]-5-oxocyclopentyl]heptanoic acid
  • (11R)-11α,15α-Dihydroxy-9-oxoprostan-1-oic acid
  • Prostan-1-oic acid,11,15-dihydroxy-9-oxo-, (11a,15S)-
CAS:
19313-28-1
MF:
C20H36O5
MW:
356.5
Mol File:
19313-28-1.mol
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15(R)-PROSTAGLANDIN E1 Chemical Properties

Boiling point:
541.4±35.0 °C(Predicted)
Density 
1.075±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
Ethyl Acetate, Methanol, Tetrahydrofuran
form 
Colorless to pale yellow oil
pka
4.77±0.10(Predicted)
Stability:
Volatile
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15(R)-PROSTAGLANDIN E1 Usage And Synthesis

Description

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.

Uses

Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.

Definition

ChEBI: 13,14-Dihydro PGE1 is a prostanoid.

15(R)-PROSTAGLANDIN E1Supplier

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