Misoprostol Acid Chemical Properties

Boiling point:

538.3±50.0 °C(Predicted)

Density 

1.118±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Chloroform

form 

Yellow viscous oil.

pka

4.77±0.10(Predicted)

color 

Pale Yellow

Stability:

Temperature Sensitive

Safety Information

Hazard Codes 

T

Risk Statements 

45-60-61-25-36/37/38

Safety Statements 

53-22-36/37/39-45-26

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

2

HazardClass 

6.1

Misoprostol Acid Usage And Synthesis

Description

Misoprostol is a prostaglandin E₁ analog with agonist activity mediated by EP₂, EP₃, and EP₄ receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED₅₀ = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC₅₀ = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC₅₀ = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.

Chemical Properties

Pale Yellow Gel

Uses

A metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration

Uses

A cytoprotective prostaglandin PGE1 analogue.

Uses

Misoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.

Biochem/physiol Actions

Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent.

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