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Misoprostol Acid

Basic information Safety Supplier Related

Misoprostol Acid Basic information

Product Name:
Misoprostol Acid
Synonyms:
  • MISOPROSTOL FREE ACID
  • (+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1
  • (11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic Acid
  • (-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E
  • MISOPROSTOL ACID
  • (+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E1
  • Misoprostol free acid,(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1
  • Misoprostol Acid (10 mg in 1 mL Methyl Acetate)
CAS:
112137-89-0
MF:
C21H36O5
MW:
368.51
Product Categories:
  • Active Pharmaceutical Ingredients
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
112137-89-0.mol
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Misoprostol Acid Chemical Properties

Boiling point:
538.3±50.0 °C(Predicted)
Density 
1.118±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Chloroform
form 
Yellow viscous oil.
pka
4.77±0.10(Predicted)
color 
Pale Yellow
Stability:
Temperature Sensitive
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Safety Information

Hazard Codes 
T
Risk Statements 
45-60-61-25-36/37/38
Safety Statements 
53-22-36/37/39-45-26
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
2
HazardClass 
6.1
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Misoprostol Acid Usage And Synthesis

Description

Misoprostol is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.

Chemical Properties

Pale Yellow Gel

Uses

A metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration

Uses

A cytoprotective prostaglandin PGE1 analogue.

Uses

Misoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.

Biochem/physiol Actions

Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent.

Misoprostol Acid Supplier

J & K SCIENTIFIC LTD.
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Cato Research Chemicals Inc.
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020-81960175
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min.he@cato-chem.com
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021-61415566 800-8193336
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BOC Sciences
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16314854226
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