(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Chemical Properties

Melting point:

ca 265℃

Flash point:

143.5℃

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

Appearance

White to off-white Solid

optical activity

[α]20/D +5±1°, c = 1% in H2O

InChI

InChI=1/C5H10N2O2.2ClH/c8-5(9)4-3-6-1-2-7-4;;/h4,6-7H,1-3H2,(H,8,9);2*1H/t4-;;/s3

InChIKey

WNSDZBQLMGKPQS-RZFWHQLPSA-N

SMILES

[C@H]1(C(=O)O)NCCNC1.Cl.Cl |&1:0,r|

CAS DataBase Reference

126330-90-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

HS Code 

29335990

Storage Class

13 - Non Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Usage And Synthesis

Chemical Properties

White solid

Uses

(R)-2-Piperazinecarboxylic acid dihydrochloride can be used as a starting material for the synthesis of (R)-enantiomers of anthramycin analogs, which are potential antiproliferative agents. It can also be employed in the preparation of piperazinemethanol chiral ligands, which can be utilized in the enantioselective borane reduction of aromatic ketones, ketimine, and oxime ether.

Synthesis

As a method for the preparation of racemic 2-piperazine carboxylic acids by optical splitting, it is known to use cyclic camphorsulfonic acid as a splitting agent, racemic 2-piperazine carboxylic acids and cyclic camphorsulfonic acid are made to be dissolved in a solvent and the resultant solution is treated with activated charcoal to remove the color, after which (R)-piperazine-2-carboxylic acid dihydrochloride is precipitated.

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride(126330-90-3)Related Product Information

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