Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)-
Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)- Basic information
- Product Name:
- Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)-
- Synonyms:
-
- Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)-
- 1-broMo-2-(2-(2-(2-broMoethoxy)ethoxy) ethoxy)ethane
- Bromo-PEG4-bromide
- Br-PEG3-bromide
- Br-PEG3-Br
- 1,11-Dibromo-3,6,9-trioxaundecane
- Br-PEG3-CH2CH2Br
- CAS_31255-26-2
- CAS:
- 31255-26-2
- MF:
- C8H16Br2O3
- MW:
- 320.02
- Mol File:
- 31255-26-2.mol
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Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)- Chemical Properties
- Boiling point:
- 146 °C(Press: 0.06 Torr)
- Density
- 1.5686 g/cm3
- storage temp.
- 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C8H16Br2O3/c9-1-3-11-5-7-13-8-6-12-4-2-10/h1-8H2
- InChIKey
- IJFMWHWXEBUOKR-UHFFFAOYSA-N
- SMILES
- O(CCOCCBr)CCOCCBr
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Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)- Usage And Synthesis
Description
Bromo-PEG3-bromide is a PEG linker containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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