Melanotan 1 Chemical Properties

Density 

1.46±0.1 g/cm3(Predicted)

RTECS 

OS1830200

storage temp. 

−20°C

pka

4.43±0.10(Predicted)

form 

Solid

Water Solubility 

Soluble to 0.60 mg/ml in sterile water

Sequence

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

InChIKey

UAHFGYDRQSXQEB-LEBBXHLNSA-N

CAS DataBase Reference

75921-69-6(CAS DataBase Reference)

Safety Information

WGK Germany 

3

Melanotan 1 Usage And Synthesis

Features

Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Definition

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.

General Description

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

storage

Store at -20°C

Melanotan 1(75921-69-6)Related Product Information

• D-Phenylalanine
• Diethylstilbestrol
• Melanotan Ⅱ Actate,MelanotanⅡAcetate,Melanotan-II(MT-II),Melanotan II acetate salt,Mt-Ii(Melanotan),Melanotan 2,Melanotan Ц,MELANOTAN II
• ALPHA-MSH
• Melanotan II）,MT-I (a MSH)
• ALPHA-MSH
• Melanotan,alpha-MSH
• Melanotan II acetate
• AC-LYS-PRO-VAL-NH2
• MELANOTAN II, MT-Ⅱ
• Melanotan 1
• [Nle4, D-Phe7]alfa-MSH, Melanotan I
• MELANOTAN II TRIFLUOROACETATE SALT
• Melanotan Ⅱ
• MelanotanⅠ(α-MSH)
• Melanotan I acetate
• AC-SYS(NLE)EH(D-PHE)RWGKPVK(BIOTIN)-AMIDE