Piperazine citrate Chemical Properties

Melting point:

183-187℃

Boiling point:

208℃[at 101 325 Pa]

Density 

0.741[at 20℃]

vapor pressure 

56.928Pa

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in DMSO

form 

powder to crystal

color 

White to Almost white

Water Solubility 

54g/L at 24℃

Merck 

14,7464

LogP

-1.15

CAS DataBase Reference

144-29-6(CAS DataBase Reference)

EPA Substance Registry System

Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) (144-29-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

1

RTECS 

TL3485000

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich

Piperazine citrate Usage And Synthesis

Description

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.

Chemical Properties

Piperazine citrate is a white, crystalline powder, with not more than a slight odor. It is soluble in water, and insoluble in alcohol and in ether.

Uses

Piperazine Citrate is an anthelmintic agent used in the treatment of parasitic infections. Also used in the reduction of blood pressure.

Indications

Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.

brand name

Antepar (GlaxoSmithKline); Bryrel (Sanofi Aventis).

Flammability and Explosibility

Not classified

Mechanism of action

Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Pharmacokinetics

Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.

Piperazine citrate(144-29-6)Related Product Information

• Disodium citrate
• Sodium citrate
• CITRIC ACID ISOPROPYL ESTER
• Calcium citrate
• Potassium Citrate
• Sodium ferrous citrate
• Triethyl citrate
• Ammonium citrate dibasic
• BETAINE CITRATE
• POTASSIUM DIHYDROGEN CITRATE
• DISODIUM HYDROGEN CITRATE SESQUIHYDRATE
• AMMONIUM BISMUTH CITRATE
• Maropitant citrate hydrate
• MAGNESIUM CITRATE
• 2-Hydroxy-1,2,3-propanetricarboxylic acid/ammonia,(1:x)
• Trisodium citrate dihydrate
• PIPERAZINE CITRATE HYDRATE,PIPERAZINE CITRATE N-HYDRATE,piperazine,citrate(3:2
• Piperazine citrate