5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Chemical Properties

Melting point:

225-227°C

Boiling point:

381.2±42.0 °C(Predicted)

Density 

1.282±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

9.63±0.20(Predicted)

color 

White to Off-White

InChI

InChI=1S/C9H9NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-3,11H,4-5H2,(H,10,12)

InChIKey

UTTJAIFHRUAFED-UHFFFAOYSA-N

SMILES

N1C2=C(C(O)=CC=C2)CCC1=O

CAS DataBase Reference

30389-33-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HS Code 

2933499090

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Usage And Synthesis

Chemical Properties

Off-white Solid

Uses

Carteolol (C184450) metabolite.

Definition

ChEBI: 5-hydroxy-3,4-dihydro-2(1h)-quinolinone is a quinolone and a hydroxyquinoline.

Synthesis

To a 100 ml three-necked flask were added 3,4,7,8-tetrahydro-2,5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml). After stirring to dissolve in the ice bath for 10min, slowly add a dropwise N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature. Water was added (the amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Yield 92.7percent).

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one(30389-33-4)Related Product Information

• 5-HYDROXY-2(1H)-QUINOLINONE
• 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane BroMide
• 7-Hydroxyquinolinone
• 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE
• Brexpiprazole Impurity 20
• Thianaphthene
• Brexpiprazole Impurity
• Brexpiprazole Impurity 2
• 7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one
• Brexpiprazole sulfoxide impurity
• (E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE
• 1.1'-Binaphthyl-2.2'-diphemyl phosphine
• 8-hydroxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one
• 4-BROMO-BENZO[B]THIOPHENE
• 7,7'-(butane-1,4-diylbis(oxy))bis(quinolin-2(1H)-one)
• 2(1H)-Quinolinone,7-(4-chlorobutoxy)-
• Brexpiprazole (3,4)-Dihydro-2(1H)-quinolinone
• 1,4-di(benzo[b]thiophen-4-yl)piperazine