QL47 Chemical Properties

Boiling point:

706.2±60.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

form 

Powder

pka

4?+-.0.20(Predicted)

color 

Light yellow to yellow

InChI

1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3

InChIKey

RTRNJQOBEOISFQ-UHFFFAOYSA-N

SMILES

[n]1(ncc(c1)c2cc3c4[n]([c](ccc4cnc3cc2)=O)c5cc6c(cc5)CCN6C(=O)C=C)C

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

QL47 Usage And Synthesis

Uses

QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM[1][2][3].

Definition

ChEBI: 9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone is a naphthyridine derivative.

Biological Activity

Cell permeable: yes', 'Primary Target
BMX & BTK', 'Reversible: no

References

[1] Liang Y, et al. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017;8(3):344-349. Published 2017 Feb 3. DOI:10.1021/acsmedchemlett.7b00008
[2] de Wispelaere M, et al. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020;295(6):1694-1703. DOI:10.1074/jbc.RA119.011132
[3] Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014;9(5):1086-1091. DOI:10.1021/cb4008524