α-Decitabine Chemical Properties

Melting point:

>174°C (dec.)

Boiling point:

485.8±55.0 °C(Predicted)

Density 

1.90±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Methanol (Slightly, Heated), Water

form 

Solid

pka

14.02±0.60(Predicted)

color 

White

Major Application

pharmaceutical (small molecule)

InChI

1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)

InChIKey

XAUDJQYHKZQPEU-UHFFFAOYSA-N

SMILES

N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO

Safety Information

WGK Germany 

WGK 3

Storage Class

13 - Non Combustible Solids

α-Decitabine Usage And Synthesis

Uses

2-Deoxy-D-α-ribopyranosyl-5-azacytosine is an isomer of 2-Deoxy-D-β-ribopyranosyl-5-azacytosine (D253525), an impurity of Decitabine and potentially carcinogenic.

Uses

α-Decitabine is shown to inhibit DNA methylation resulting in an effective anticancer agent.

Definition

ChEBI: 4-amino-1-[4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,3,5-triazin-2-one is a member of triazines.

α-Decitabine(22432-95-7)Related Product Information

• 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-4-methoxy-1,3,5-triazin-2(1H)-one
• 5-Aza-2'-deoxyuridine
• Methyl-2-deoxy-alpha-D-ribofuranoside
• 5-Aza-2'-deoxycytidine
• ribal
• Decitabine Impurity 6 (alpha-D-Erythro-Pentopyranoside-Methyl-2-Deoxy-bis(4-methylbenzoate))
• 4-[(2-naphthalen-2-yloxyacetyl)amino]benzamide
• Decitabine Impurity 4 (Methyl 2-deoxy-beta-D-Ribopyranoside)
• Decitabine Impurity 2 (beta-Isomer)
• 1-O-Acetyl-3,5-bis-(4-chlorobenzoyl)-2-deoxy-D-ribose
• 4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one
• 3',5'-di-o-p-chlorobenzoyl-2-deoxy-5-azacytosine
• METHYL 4-CHLOROBENZOATE
• 2-Deoxy-beta-D-erythro-pentofuranose 1-acetate 3,5-bis(4-chlorobenzoate)
• 3-Toluoyl Decitabine
• Methyl 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribo-furanoside
• 4-AMINO-6-METHYL-1,3,5-TRIAZIN-2-OL
• Methyl 2-deoxy-beta-D-erythro-pentopyranoside bis(4-methylbenzoate)