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α-Decitabine

Basic information Safety Supplier Related

α-Decitabine Basic information

Product Name:
α-Decitabine
Synonyms:
  • Decitabine alpha-Isomer
  • Decitabine Impurity 4(Alpha-Isomer)
  • Decitabine Alpha Isomer Impurity
  • 4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
  • alpha-Decitabine
  • Decitabine Impurity 38
  • 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-α-D-erythro-pentofuranosyl)-
  • 1-(2-Deoxy-a-D-ribofuranosyl)-5-azacytosine
CAS:
22432-95-7
MF:
C8H12N4O4
MW:
228.21
Product Categories:
  • Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
22432-95-7.mol
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α-Decitabine Chemical Properties

Melting point:
>174°C (dec.)
Boiling point:
485.8±55.0 °C(Predicted)
Density 
1.90±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Methanol (Slightly, Heated), Water
form 
Solid
pka
14.02±0.60(Predicted)
color 
White
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α-Decitabine Usage And Synthesis

Uses

2-Deoxy-D-α-ribopyranosyl-5-azacytosine is an isomer of 2-Deoxy-D-β-ribopyranosyl-5-azacytosine (D253525), an impurity of Decitabine and potentially carcinogenic.

Uses

α-Decitabine is shown to inhibit DNA methylation resulting in an effective anticancer agent.

Definition

ChEBI: 4-amino-1-[4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,3,5-triazin-2-one is a member of triazines.

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