Optovin Chemical Properties

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Soluble in DMSO (up to 30 mg/ml)

pka

7.65±0.50(Predicted)

form 

solid

color 

Tan

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

InChI

1S/C15H13N3OS2/c1-9-6-11(7-13-14(19)17-15(20)21-13)10(2)18(9)12-4-3-5-16-8-12/h3-8H,1-2H3,(H,17,19,20)

InChIKey

YISGMOZSGOGYOU-UHFFFAOYSA-N

SMILES

S1C(=S)NC(=O)C1=Cc2c([n](c(c2)C)c3cnccc3)C

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Optovin Usage And Synthesis

Description

Optovin (348575-88-2) is a reversible photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50?= 2 μM) and mice,?in vivo. Photodetection is performed by sensory neurons expressing the TRPA1 cation channel which is activated via structure-dependent photochemical reactions with redox-sensitive cysteine residues.1

Uses

Optovin activates human TRPA1 via structure-dependent photochemistry.

Definition

ChEBI: Optovin is a member of the class of thiazolidinone that is rhodanine in which the two methylene hydrogens have been replaced by a 2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene group. A TRPA1 ligand that can be reversibly photoactivated. It has a role as a TRPA1 channel agonist. It is a member of pyrroles, a member of pyridines, an olefinic compound and a thiazolidinone. It is functionally related to a rhodanine.

in vivo

storage

Store at +4°C

References

[1] DAVID KOKEL. Photochemical activation of TRPA1 channels in neurons and animals[J]. Nature chemical biology, 2013, 9 4: 257-263. DOI:10.1038/nchembio.1183

Optovin(348575-88-2)Related Product Information

• A 967079
• Minoxidil
• 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
• Isradipine