Basic information Safety Supplier Related

(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)

Basic information Safety Supplier Related

(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) Basic information

Product Name:
(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)
Synonyms:
  • (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)
  • (S)-3-AMINO-4-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W140
  • W140
  • W140 (TFA)
CAS:
909725-64-0
MF:
C18H28F3N2O6P
MW:
456.4
Mol File:
909725-64-0.mol
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(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) Chemical Properties

storage temp. 
Store at -20°C
solubility 
Ethanol: 0.15 mg/ml
form 
A crystalline solid
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(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) Usage And Synthesis

Description

W140 is the inactive enantiomer of the sphingosine-1-phosphate receptor 1 (S1P1) antagonist W146 .1 It only weakly binds to S1P1 (Ki = 4.6 μM for the human receptor). W140 has been used as a negative control in vitro and in vivo in the study of S1P1 signaling.1,2

References

1. Sanna, M.G., Wang, S.K., Gonzalez-Cabrera, P.J., et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo Nat. Chem. Biol. 2(8),434-441(2006).
2. Li, C., Chi, X.X., Xie, W., et al. Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor J. Neurophysiol. 108(5),1473-1483(2012).

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