PHACLOFEN Chemical Properties

Melting point:

249-252 °C

Boiling point:

467.1±55.0 °C(Predicted)

Density 

1.432±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

0.1 M HCl: 13.3 mg/mL

form 

solid

pka

1.87±0.10(Predicted)

color 

white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

PHACLOFEN Usage And Synthesis

Uses

Phaclofen is a selective GABAB?receptor antagonist.

General Description

Phaclofen is a phosphonic acid derivative of baclofen.

Biological Activity

Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ).

Biochem/physiol Actions

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.

PHACLOFEN(114012-12-3)Related Product Information

• 3-Aminopropylphosphonic acid
• PHACLOFEN
• P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE
• (2-phenylethyl)phosphonic acid