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Arisantetralone C

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Arisantetralone C Basic information

Product Name:
Arisantetralone C
Synonyms:
  • Arisantetralone C
  • Schisandrone
  • 1(2H)-Naphthalenone, 4-(3,4-dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-2,3-dimethyl-, (2S,3S,4R)-
  • (2S,3S,4R)-4-(3,4-Dimethoxyphenyl)-7-hydroxy-6-methoxy-2,3-dimethyl-3,4-dihydronaphthalen-1(2H)-one
CAS:
98619-25-1
MF:
C21H24O5
MW:
356.41
Mol File:
98619-25-1.mol
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Arisantetralone C Chemical Properties

Melting point:
180-181℃
Boiling point:
508.2±50.0 °C(Predicted)
Density 
1.159±0.06 g/cm3(Predicted)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Cryst.
pka
9.38±0.70(Predicted)
color 
White to off-white
InChI
InChI=1S/C21H24O5/c1-11-12(2)21(23)15-9-16(22)18(25-4)10-14(15)20(11)13-6-7-17(24-3)19(8-13)26-5/h6-12,20,22H,1-5H3/t11-,12+,20-/m1/s1
InChIKey
DRKPZVVNEGETTG-XAAFQQQXSA-N
SMILES
C1(=O)C2=C(C=C(OC)C(O)=C2)[C@@H](C2=CC=C(OC)C(OC)=C2)[C@H](C)[C@@H]1C
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Arisantetralone C Usage And Synthesis

Uses

Schisandrone is a new 4-?aryltetralone lignan isolated from the dried fruits of Schisandra sphenanthera. Schisandrone improves learning and memory abilities of rats with Alzheimer-like disease.

in vivo

Schisandrone (40 mg/kg, s.c.) combined with antibiotic Ceftiofur exhibits a significant therapeutic effect on S. aureusinfection in mice[2].

Animal Model:S. aureus-infected mice[2]
Dosage: 40 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Combined with ceftiofur reduced The MIC of ceftiofur, from 32 μg/mL to 2 μg/mL.
Showed the survival rate of 30%.

target

NF-kB | NOS | Beta Amyloid

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