WUWEIZISU C
WUWEIZISU C Basic information
- Product Name:
- WUWEIZISU C
- Synonyms:
-
- SCHIZANDRIN C
- WUWEIZISU C
- ,8-dimethyl-
- cycloocta(1,2-f:3,4-f’)bis(1,3)benzodioxole6,7,8,9-tetrahydro-1,13-dimethoxy-7
- (6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole
- (S)-(-)-Schisandrin C
- Schisandrin C (Schizandrin-C
- Schisandrin C (S)-(-)-Schisandrin C
- CAS:
- 61301-33-5
- MF:
- C22H24O6
- MW:
- 384.42
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- Miscellaneous Natural Products
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 61301-33-5.mol
WUWEIZISU C Chemical Properties
- Melting point:
- 122-123℃
- Boiling point:
- 549.2±50.0 °C(Predicted)
- Density
- 1.232
- solubility
- DMSO : 8.33 mg/mL (21.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- powder
- color
- White
- LogP
- 5.623 (est)
WUWEIZISU C Usage And Synthesis
Description
Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities. It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM. Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells. It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; ), TNF-α, IL-1β, and IL-6 in mouse primary microglia. In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.
Uses
Schisandrin C potently inhibits proprotein convertase subtillsin-kexin type 9 (PCSK9) mRNA expression. Also, it displays strong protective effects in SH-SY5Y cells against serum and glucose deprivation (SGD) injury.
WUWEIZISU CSupplier
- Tel
- 028-83133020 18280298385
- 1223808415@qq.com
- Tel
- 021-20908456
- sales@BioChemBest.com
- Tel
- 13355009207 13355009207
- 3007715519@qq.com
- Tel
- 400-1166-196 18981987031
- cdhxsj@163.com
- Tel
- +86-0755-89668383
- sales@sungening.com
WUWEIZISU C(61301-33-5)Related Product Information
- WUWEIZISU B,WUWEIZISU B 98.0% BY HPLC
- Schisandrin
- schisanhenol
- WUWEIZISU A
- Schisantherin A
- (5S)-6α,7β-Dimethyl-1,2,3,11,12-pentamethoxy(5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene)-5α,6β,10-triol 5-benzoate
- Gomisin A
- 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)-
- Arisantetralone C
- 3,5,6,6-tetraMethyl-4,5,5a,6,7,8-hexahydrocyclopenta[c]pentalen-2(1H)-one
- schisantherin D
- SchisandraeChinensis polysaccharides
- Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer
- 4,4'-Biphenol
- 4-HYDROXY-4'-METHOXYBIPHENYL
- 4,4'-Dimethoxybiphenyl
- Masoprocol
- 2,2'-DIMETHOXYBIPHENYL