Ethyl 1-benzylpiperidine-4-carboxylate Chemical Properties

Boiling point:

122°C (0.5 mmHg)

Density 

1.037 g/mL at 25 °C

refractive index 

1.5120-1.5160

Flash point:

>110℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Hexanes (Slightly), Methanol (Slightly)

form 

clear liquid

pka

7.93±0.10(Predicted)

color 

Colorless to Light red

CAS DataBase Reference

24228-40-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-25

Safety Statements 

24/25-45

RIDADR 

UN 2810 6.1 / PGIII

Hazard Note 

Irritant

HS Code 

29333990

Ethyl 1-benzylpiperidine-4-carboxylate Usage And Synthesis

Synthesis

Ethyl isonipecotate (50 g, 0.31 mol) was dissolved in toluene (150 mL) in a round bottom flask, charged with potassium carbonate (60 g, 0.43 mol) and stirred for 15 min. Benzyl chloride (42 g, 0.31 mol) was charged and the reaction mass was refluxed for 4 h at 100 °C. Upon completion of the reaction as marked by TLC (hexane:ethyl acetate; 2:1), the reaction mass was cooled to room temperature and quenched with water (100 mL), stirred and the organic phase was separated. The aqueous phase was again extracted with toluene (100 mL). Combined organic phase was washed twice with saturated brine solution (50 mL). Remove toluene in vacuo to obtain Ethyl N-benzylpiperidine-4-carboxylate ( 6.97 g, 91 %) as a yellow liquid.

Chemical Properties

Colourless Oil

Ethyl 1-benzylpiperidine-4-carboxylate(24228-40-8)Related Product Information

• Ethyl cyanoacetate
• Ethyl acrylate
• Ethyl cyanoformate
• Ethanol
• Ethylparaben
• Urethane
• Benzocaine
• Ethyl nipecotate
• ISOXADIFEN-ETHYL
• Ethyl acetate
• N-Benzyl-4-piperidone
• Ethyl pyruvate
• Ethyl formate
• RESMETHRIN
• Ethyl 4-piperidinecarboxylate
• 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
• Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride
• Ethyl chloroformate