PFK-158
PFK-158 Basic information
- Product Name:
- PFK-158
- Synonyms:
-
- PFK-158
- PFK-158, ACT-PFK-158
- (2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one
- PFK-158;PFK 158
- PFK-158 free base
- 2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-
- (E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one
- p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
- CAS:
- 1462249-75-7
- MF:
- C18H11F3N2O
- MW:
- 328.29
- Mol File:
- 1462249-75-7.mol
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PFK-158 Chemical Properties
- Boiling point:
- 466.3±45.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
- form
- A crystalline solid
- pka
- 2.46±0.10(Predicted)
- color
- White to light yellow
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PFK-158 Usage And Synthesis
Description
PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.
PFK-158Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
Shanghai JiYi Biotechnology Co. Ltd.
- Tel
- 13621943973
- sales@shjiyipharmatech.com
Hunan Cangood Medical Technology Ltd.
- Tel
- 400-026-9899
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266