A-196 Chemical Properties

Boiling point:

584.6±45.0 °C(Predicted)

Density 

1.399±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO (up to 5 mg/ml)

form 

powder

pka

3.96±0.30(Predicted)

color 

white to light brown

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

InChI

1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)

InChIKey

ABGOSOMRWSYAOB-UHFFFAOYSA-N

SMILES

ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1

Safety Information

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

WGK 3

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

A-196 Usage And Synthesis

Description

A-196 is a selective inhibitor of SUV420H1 and SUV420H2 (IC₅₀s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC₅₀ values less than 1 μM. For more information on A-196 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2043 (A-197), for A-196 is also available exclusively through the SGC. You can submit a request to receive the negative control here.

Uses

A-196 is a potent inhibitor of SUV420H1.

Biochem/physiol Actions

A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. For full characterization details, please visit the A-196 probe summary on the Structural Genomics Consortium (SGC) website.SGC2043 is the negative control for the active probe, A-196. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

References

[1] KENNETH D BROMBERG. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity[J]. Nature chemical biology, 2017, 13 3: 317-324. DOI:10.1038/nchembio.2282

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