MS049 Chemical Properties

Boiling point:

352.6±37.0 °C(Predicted)

Density 

1.03±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: ≥ 31 mg/mL (124.82 mM)

pka

10.48±0.10(Predicted)

form 

Solid

color 

Light yellow to yellow

Water Solubility 

H2O: 20mg/mL, clear

InChI

1S/C15H24N2O.ClH/c1-16-9-12-17-10-7-15(8-11-17)18-13-14-5-3-2-4-6-14;/h2-6,15-16H,7-13H2,1H3;1H

InChIKey

FJZNVFFTIKWXMA-UHFFFAOYSA-N

SMILES

CNCCN(CC1)CCC1OCC2=CC=CC=C2.[H]Cl

Safety Information

WGK Germany 

WGK 3

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

MS049 Usage And Synthesis

Uses

MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells[1].

Biological Activity

MS049 is a potent and selective inhibitor of protein arginine methyltransferases (PRMTs) PRMT 4 and PRMT6. MS049 is active in cells. For full characterization details, please visit the MS049 probe summary on the Structural Genomics Consortium (SGC) website.

MS049N is the negative control for the active probe, MS049. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

IC 50

PRMT4: 34 nM (); PRMT6: 43 nM (); PRMT8: 1600 nM ()

References

[1] Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15. DOI:10.1021/acs.jmedchem.6b01033

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