SirReal2 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml

form 

A crystalline solid

color 

Off-white to light yellow

SirReal2 Usage And Synthesis

Description

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC₅₀ = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.

Uses

SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.

storage

Store at -20°C

SirReal2(709002-46-0)Related Product Information

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