Basic information Safety Supplier Related

SirReal2

Basic information Safety Supplier Related

SirReal2 Basic information

Product Name:
SirReal2
Synonyms:
  • SirReal2
  • Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-
  • 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
  • 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
  • SirReal2 >=98% (HPLC)
  • Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2
  • 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
CAS:
709002-46-0
MF:
C22H20N4OS2
MW:
420.55
Mol File:
709002-46-0.mol
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SirReal2 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form 
A crystalline solid
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SirReal2 Usage And Synthesis

Description

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.

Uses

SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.

storage

Store at -20°C

SirReal2Supplier

AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Email
info@adooq.cn
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Email
info@SuperLan-chem.com
Angel Pharmatech, Ltd.
Tel
17317130613
Email
3358272972@qq.com
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
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SirReal2(709002-46-0)Related Product Information