Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Biochemical Reagents >  Agonist Inhibitors >  NMS-P118

NMS-P118

Basic information Safety Supplier Related

NMS-P118 Basic information

Product Name:
NMS-P118
Synonyms:
  • 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-6-fluoro-3-oxoisoindoline-4-carboxamide
  • NMS-P118
  • 2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide
  • NMS-P118; NMS-P 118; NMS P118
  • 2-[1-(4,4-difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide
  • CS-2354
  • 1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-
  • NMS-P118,inhibit,NMS P118,PARP,NMSP118,Inhibitor,poly ADP ribose polymerase,NMS-P-118
CAS:
1262417-51-5
MF:
C20H24F3N3O2
MW:
395.42
Mol File:
1262417-51-5.mol
More
Less

NMS-P118 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: slightly soluble
form 
A crystalline solid
color 
White to off-white
InChI
InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)
InChIKey
ARYVAQSYRLZVQD-UHFFFAOYSA-N
SMILES
C1C2=C(C(C(N)=O)=CC(F)=C2)C(=O)N1C1CCN(C2CCC(F)(F)CC2)CC1
More
Less

NMS-P118 Usage And Synthesis

Uses

2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide is a nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. PARP-1 is involved with the signaling and repair of DNA and a target in oncology.

in vivo

NMS-P118 is a potent (KD=0.009 μM) PARP-1 inhibitor, showing 150-fold selectivity over PARP-2 (KD=1.39 μM). NMS-P118 possesses excellent pharmacokinetic profile and nearly complete oral bioavailability both in mice and rats. It proved to be highly efficacious in vivo both as single agent in MDA-MB-436 human breast cancer tumors and in combination with temozolomide in CAPAN-1 human pancreatic tumors growing as xenografts in the mouse. The compound is well tolerated at highly efficacious doses and is endowed with an excellent ADME profile[1].

IC 50

PARP-1: 9 nM (Kd); PARP-2: 1390 nM (Kd)

NMS-P118Supplier

Shanghai Jinyin Biological Technology Co., Ltd Gold
Tel
021-20986266 18019349802
Email
814527417@qq.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
More
Less

NMS-P118(1262417-51-5)Related Product Information