N-T-BOC-PYRROLE Chemical Properties

Boiling point:

91-92 °C20 mm Hg(lit.)

Density 

1 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.4685(lit.)

Flash point:

167 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Acetonitrile, Dichloromethane, Ethyl Acetate, Methanol, Tetrahydrofuran

form 

Solution

pka

-6.10±0.70(Predicted)

color 

Colorless to yellow

InChIKey

IZPYBIJFRFWRPR-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich

N-T-BOC-PYRROLE Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Pyrrole-1-carboxylic Acid tert-Butyl Ester is an intermediate in the synthesis of pyrrole derived anti-cancer Agent.

Uses

N-Boc-pyrrole was used in the synthesis of 1-(tert-butoxycarbonyl)-1H-pyrrol-2-ylboronic acid by treating with n-BuLi and subsequent reaction with trimethyl borate.
It may be used as starting material in the synthesis of the following:

• tropane drivatives
• N-boc-2-(4-methoxyphenyl)pyrrole
• N-boc-pyrrol-2-ylboronic acid

Synthesis Reference(s)

The Journal of Organic Chemistry, 31, p. 764, 1966 DOI: 10.1021/jo01341a027

General Description

N-Boc-pyrrole is an N-protected pyrrole. It undergoes Diels–Alder reaction with enantiomerically pure allene-1,3-dicarboxylates to form endo-adducts with retention in configurations at two newly generated stereogenic centers. It also undergoes cyclopropanation with methyl phenyldiazoacetate to form both monocyclopropane and dicyclopropane. Its Ir-catalyzed C-H borylation followed by cross coupling with 3-chlorothiophene to form biheterocycle has been reported.

N-T-BOC-PYRROLE(5176-27-2)Related Product Information

• tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
• 1-BOC-2,3-DIHYDRO-7-INDOLECARBALDEHYDE
• MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
• N-BOC-INDOLINE-7-CARBOXYLIC ACID
• 1-Boc-Pyrrolidine
• Fmoc-Trp(Boc)-OH
• TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE
• N-Boc-2-pyrroleboronic acid
• Z-TRP(BOC)-OH DCHA
• H-TRP(BOC)-OH
• Fmoc-D-Trp(Boc)-OH
• BOC-TRP(BOC)-OH
• 1-BOC-PYRROLE-2-BORONIC ACID, PINACOL ESTER
• H-D-TRP(BOC)-OH
• H-TRP(BOC)-OTBU HCL
• N-T-BOC-PYRROLE
• H-TRP(BOC)-2-CLTRT RESIN
• FMOC-TRP(BOC)-OPFP