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Fmoc-Trp(Boc)-OH

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Fmoc-Trp(Boc)-OH Basic information

Product Name:
Fmoc-Trp(Boc)-OH
Synonyms:
  • FMOC-TRP(BOC)-OH
  • FMOC-TRP(BOC)
  • FMOC-TRYPTOPHAN(BOC)-OH
  • FMOC-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN
  • FMOC-N-IN-BOC-L-TRYPTOPHAN
  • FMOC-N-BOC-L-TRYPTOPHAN
  • FMOC-L-TRP(BOC)
  • FMOC-L-TRP(BOC)-OH
CAS:
143824-78-6
MF:
C31H30N2O6
MW:
526.58
EINECS:
604-383-0
Product Categories:
  • Tryptophan [Trp, W]
  • Fmoc-Amino Acids and Derivatives
  • Amino Acids
  • Amino Acids (N-Protected)
  • Biochemistry
  • Fmoc-Amino Acids
  • Fmoc-Amino acid series
Mol File:
143824-78-6.mol
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Fmoc-Trp(Boc)-OH Chemical Properties

Melting point:
ca 97℃
alpha 
-21 º (c=1%, DMF)
Density 
1.28±0.1 g/cm3(Predicted)
refractive index 
-20 ° (C=1, DMF)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.71±0.10(Predicted)
form 
Solid
color 
White to Orange to Green
optical activity
[α]20/D 21±2°, c = 1% in DMF
Sensitive 
Moisture Sensitive
BRN 
7698009
InChIKey
ADOHASQZJSJZBT-SANMLTNESA-N
SMILES
C(O)(=O)[C@H](CC1C2=C(C=CC=C2)N(C(OC(C)(C)C)=O)C=1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference
143824-78-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-51/53-43
Safety Statements 
22-24/25-36/37/39-27-26-61-37-24
RIDADR 
3077
WGK Germany 
3
10-21
HazardClass 
9
HS Code 
29339900

MSDS

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Fmoc-Trp(Boc)-OH Usage And Synthesis

Chemical Properties

White solid

Uses

Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.

Uses

Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).

General Description

The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.



The product number for this product was previously 04-12-1103.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Fmoc-Trp(Boc)-OHSupplier

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