Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH Basic information
- Product Name:
- Fmoc-Trp(Boc)-OH
- Synonyms:
-
- FMOC-TRP(BOC)-OH
- FMOC-TRP(BOC)
- FMOC-TRYPTOPHAN(BOC)-OH
- FMOC-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN
- FMOC-N-IN-BOC-L-TRYPTOPHAN
- FMOC-N-BOC-L-TRYPTOPHAN
- FMOC-L-TRP(BOC)
- FMOC-L-TRP(BOC)-OH
- CAS:
- 143824-78-6
- MF:
- C31H30N2O6
- MW:
- 526.58
- EINECS:
- 604-383-0
- Product Categories:
-
- Tryptophan [Trp, W]
- Fmoc-Amino Acids and Derivatives
- Amino Acids
- Amino Acids (N-Protected)
- Biochemistry
- Fmoc-Amino Acids
- Fmoc-Amino acid series
- Mol File:
- 143824-78-6.mol
Fmoc-Trp(Boc)-OH Chemical Properties
- Melting point:
- ca 97℃
- alpha
- -21 º (c=1%, DMF)
- Density
- 1.28±0.1 g/cm3(Predicted)
- refractive index
- -20 ° (C=1, DMF)
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 3.71±0.10(Predicted)
- form
- Solid
- color
- White to Orange to Green
- optical activity
- [α]20/D 21±2°, c = 1% in DMF
- Sensitive
- Moisture Sensitive
- BRN
- 7698009
- InChIKey
- ADOHASQZJSJZBT-SANMLTNESA-N
- SMILES
- C(O)(=O)[C@H](CC1C2=C(C=CC=C2)N(C(OC(C)(C)C)=O)C=1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- CAS DataBase Reference
- 143824-78-6(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-51/53-43
- Safety Statements
- 22-24/25-36/37/39-27-26-61-37-24
- RIDADR
- 3077
- WGK Germany
- 3
- F
- 10-21
- HazardClass
- 9
- HS Code
- 29339900
MSDS
- Language:English Provider:SigmaAldrich
Fmoc-Trp(Boc)-OH Usage And Synthesis
Chemical Properties
White solid
Uses
Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.
Uses
Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).
General Description
The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.
The product number for this product was previously 04-12-1103.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
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Fmoc-Trp(Boc)-OH(143824-78-6)Related Product Information
- Fmoc-Lys(Boc)-OH
- L-Tryptophan
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- L-5-Hydroxytryptophan
- Fmoc-Phe-OH
- Nalpha-Fmoc-Ndelta-trityl-L-glutamine
- L-Fmoc-Aspartic acid alpha-tert-butyl ester
- METHOXYCARBONYLSULFENYL CHLORIDE
- Cyhalofop-butyl
- Butyl acetate
- N-(9-Fluorenylmethoxycarbonyloxy)succinimide
- Boc-Aib-OH
- 2-Butoxyethanol
- Buprofezin
- tert-Butanol