Boc-aminooxy-PEG1-Propargyl Chemical Properties

Density 

1.063±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

Boc-aminooxy-PEG1-Propargyl Usage And Synthesis

Description

t-Boc-aminooxy-PEG1-propargyl is a click chemistry PEG linker with a t-Boc-aminooxy group. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The t-Boc aminooxy group can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Boc-aminooxy-PEG1-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651

Boc-aminooxy-PEG1-Propargyl(1895922-72-1)Related Product Information

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• t-Boc-aminooxy-PEG5-propargyl
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