Boc-aminooxy-PEG2-Propargyl Chemical Properties

Density 

1.072±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

Boc-aminooxy-PEG2-Propargyl Usage And Synthesis

Description

t-Boc-aminooxy-PEG2-propargyl is a click chemistry crosslinker. The propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. t-Boc-aminooxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Boc-aminooxy-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Boc-aminooxy-PEG2-Propargyl(1895922-74-3)Related Product Information

• Boc-Aminooxy-PEG2-amine
• Boc-aminooxy-PEG1-Propargyl
• Boc-Aminooxy-PEG2-Azide