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ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Pharmaceutical Impurity Reference Standards >  (R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine

(R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine

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(R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine Basic information

Product Name:
(R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
Synonyms:
  • (αR)-7,8-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine
  • 1-(7,8-Dihydro-napthalen-1-yl)-ethyl]- [3-(3-trifluoromethyl-phenyl)]-amine hydrochloride
  • (E)-N-(1-(5,6-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)acrylamide hydrochloride
  • (R)-1-(naphthalen-1-yl)-N-(3-(trifluoromethyl)benzyl)ethan-1-aminehydrochloride
  • (R)-1-(phthalen-1-yl)-N-(3-(trifluoromethyl)benzyl)ethan-1-aminehydrochloride
  • "(R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)
  • 1-Naphthalenemethanamine, 7,8-dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (αR)-
  • (alphaR)-7,8-Dihydro-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine
CAS:
802918-35-0
MF:
C22H24F3N
MW:
359.4278696
Mol File:
802918-35-0.mol
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(R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine Chemical Properties

Boiling point:
427.1±45.0 °C(Predicted)
Density 
1.138±0.06 g/cm3(Predicted)
pka
9.48±0.29(Predicted)
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(R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine Usage And Synthesis

Uses

(αR)-7,8-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine is synthetically prepared though a double bond migration in Heck reaction during the preparation of cinacalcet congeners. This enantiomerically pure material is seperated from its counter part, (αR)-5,6-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine (D455335) using HPLC.

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