Hydroxy-PEG5-methyl ester Chemical Properties

Boiling point:

414.8±40.0 °C(Predicted)

Density 

1.109±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

14.36±0.10(Predicted)

color 

Colorless to light yellow

Hydroxy-PEG5-methyl ester Usage And Synthesis

Description

Hydroxy-PEG5-methyl ester is a PEG linker containing a hydroxyl group and a methyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Methyl ester can be hydrolyzed under strong basic condition.

Uses

Hydroxy-PEG5-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Hydroxy-PEG5-methyl ester(2100306-80-5)Related Product Information

• Hydroxy-PEG1-methyl ester
• HO-PEG5-tBu
• Hydroxy-PEG4-methyl ester