N3-PEG12-OH Chemical Properties

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C24H49N3O12/c25-27-26-1-3-29-5-7-31-9-11-33-13-15-35-17-19-37-21-23-39-24-22-38-20-18-36-16-14-34-12-10-32-8-6-30-4-2-28/h28H,1-24H2

InChIKey

AFUKFRGNHZRMCW-UHFFFAOYSA-N

SMILES

C(OCCOCCOCCOCCOCCOCCO)COCCOCCOCCOCCOCCN=[N+]=[N-]

N3-PEG12-OH Usage And Synthesis

Uses

Azide-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG12-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N3-PEG12-OH(1821464-55-4)Related Product Information

• N3-PEG12-N3
• Azido-PEG12-Br
• Azido-PEG12-NHS ester
• Azide-PEG12-Tos
• N3-PEG12-Hydrazide
• N3-PEG12-CH2CH2COOH
• Azido-PEG12-NHBoc
• Azido-PEG12-Amine
• Azido-PEG12-t-butyl ester