OLIGOMYCIN C
OLIGOMYCIN C Basic information
- Product Name:
- OLIGOMYCIN C
- Synonyms:
-
- 12-Deoxyoligomycin A
- Oligmycin C
- OLIGOMYCIN C
- OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES
- Oligomycin A, 12-deoxy-
- Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
- Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
- CAS:
- 11052-72-5
- MF:
- C45H74O10
- MW:
- 775.06
- EINECS:
- 234-276-0
- Product Categories:
-
- Antibiotics
- Antibiotics A to
- Antibiotics by Application
- Antibiotics N-SAntibiotics
- AntifungalAntibiotics
- Antineoplastic and Immunosuppressive AntibioticsAntibiotics
- Chemical Structure Class
- Inhibits an EnzymeAntibiotics
- Macrolides
- Mechanism of Action
- Spectrum of Activity
- Mol File:
- 11052-72-5.mol
OLIGOMYCIN C Chemical Properties
- Boiling point:
- 876.2±65.0 °C(Predicted)
- Density
- 1.091 g/cm3
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- form
- White to off-white powder.
- pka
- 13.49±0.70(Predicted)
- Merck
- 13,6902
OLIGOMYCIN C Usage And Synthesis
Description
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.
Uses
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
Uses
Oligomycin C is an ATP synthetase and RVD inhibitor.
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors
References
[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.
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OLIGOMYCIN C(11052-72-5)Related Product Information
- 3-Chloro-2-methylpropene
- LIPOPOLYSACCHARIDE FROM ESCHERICHIA COLI
- Glutathione
- OLIGOMYCIN A
- oligomycin D
- oligomycin G
- OLIGOMYCIN
- oligomycin sensitivity-conferring protein
- oligomycin E
- Oligomycin F
- OLIGOMYCIN B,OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES,Oligomycin A, 28-oxo- ,Oligomycin B fromStreptomyces diastatochromogenes
- 44-homooligomycin A
- OLIGOMYCIN C
- OLIGOMYCIN A,OLIGOMYCIN COMPLEX,OLIGOMYCIN A, STREPTOMYCES DIASTATOCHROMOGENES,OLIGOMYCIN, STREPTOMYCES DIASTATOCHROMOGENES
- 44-homooligomycin B