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Naftalofos

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Naftalofos Basic information

Product Name:
Naftalofos
Synonyms:
  • e9002
  • ent25,567
  • Phosphoric acid, 1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl diethyl ester
  • phosphoric acid (1,3-dioxo-2-benzo[de]isoquinolinyl) diethyl ester
  • Phosphoric acid, N-hydroxynaphthalimide O,O-diethyl ester
  • maretin
  • n-hydroxy-naphthalimiddiethylphosphate
  • n-hydroxynaphthylimidediethylphosphate
CAS:
1491-41-4
MF:
C16H16NO6P
MW:
349.28
EINECS:
216-078-6
Mol File:
1491-41-4.mol
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Naftalofos Chemical Properties

Melting point:
174-179°
storage temp. 
0-6°C
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly)
form 
solid
Boiling point:
487.3±28.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
CAS DataBase Reference
1491-41-4(CAS DataBase Reference)
EPA Substance Registry System
Naftalofos (1491-41-4)
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Safety Information

Hazard Codes 
T
Risk Statements 
24/25
Safety Statements 
36/37-45
RIDADR 
2783
WGK Germany 
3
RTECS 
QK5775000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
chicken,LD50,oral,43300ug/kg (43.3mg/kg),PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967.
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Naftalofos Usage And Synthesis

Uses

Anthelmintic(veterinary).

Definition

ChEBI: Naftalofos is an organic heterotricyclic compound. It has a role as an anthelminthic drug.

brand name

Maretin (Bayer Animal Health).

Synthesis

Naftalofos is synthesised through a multi-step chemical process that begins with the preparation of O-ethyl phenylphosphonothioic acid, which serves as the phosphorus-containing core. This intermediate is then reacted with 2-naphthol, a hydroxylated aromatic compound, via esterification, forming the characteristic O-naphthyl linkage. After the coupling step, the crude product undergoes purification to isolate.

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