1-NAPHTHOHYDROXAMIC ACID Chemical Properties

Melting point:

176-178 °C

Density 

1.291±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: ≥5mg/mL

pka

8.91±0.30(Predicted)

form 

White solid

color 

white to tan

Safety Information

Risk Statements 

52

WGK Germany 

3

RTECS 

QJ1894500

HS Code 

2928009090

1-NAPHTHOHYDROXAMIC ACID Usage And Synthesis

Uses

1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.

Biochem/physiol Actions

1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.

1-NAPHTHOHYDROXAMIC ACID(6953-61-3)Related Product Information

• Pyrazine
• 2-Naphthohydroxamic acid, O-acetate ester
• Naftalofos
• N-HYDROXYNAPHTHALIMIDE SODIUM SALT
• N-Hydroxy-1,8-naphthalimide
• Naphthaloximidodiethyl thiophosphate
• N-Hydroxynaphthalimide triflate
• 1-NAPHTHOHYDROXAMIC ACID