MILBEMECTIN A3 Chemical Properties

Melting point:

212-215°; mp 192-194°

alpha 

D20 +106° (c = 0.25 in acetone) (Aoki); D20 +106° (acetone) (Hirama)

Boiling point:

725.5±60.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

0-6°C

solubility 

DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble

form 

A solid

pka

12.46±0.70(Predicted)

EPA Substance Registry System

Milbemycin A3 (51596-10-2)

Safety Information

RIDADR 

2588

HazardClass 

6.1(b)

PackingGroup 

III

MILBEMECTIN A3 Usage And Synthesis

Description

Milbemycin A₃ is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin A₃ is used as a nematocide and insecticide. The acaricidal and nematocidal activity of a mixture of milbemycin A₃ and milbemycin A₄ against adult spider mites, spider mite eggs, and C. elegans are reported at IC₅₀ values of 5.3, 41.1, and 9.5 μg/ml.

Uses

Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A3 is a major member of a group of analogues containing a 25-methyl substituent. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels.

Uses

Milbemycin A3 is widely used as a pesticides in agriculture. Milbemycin A3 (Milbemycin EP Impurity B) is an antibiotic with acaricidal activity.

Definition

ChEBI: Milbemycin A3 is a milbemycin.

MILBEMECTIN A3(51596-10-2)Related Product Information

• MilbeMycin A3 OxiMe
• MilbeMycin A4 OxiMe
• MILBEMECTIN A4
• Miconazole IMpurity B
• MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
• 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxylic acid
• 1,6-Dihydro-2-(hydroxyMethyl)-6-oxo-[3,4'-bipyridine]-5-carbonitrile
• Milbemycin oxime
• Isoconazole
• Milbemycin EP Impurity D
• Milrinone Impurity 13
• Miconazole Impurity
• Miconazole IMpurity I
• 5-Decyano 5-(Ethyl Formate) Milrinone
• Milrinone Impurity 17
• Milrinone Impurity 14
• Milbemycin EP Impurity E
• Miconazole EP Impurity E