AC-LEU-VAL-LYS-ALDEHYDE Chemical Properties

Boiling point:

665.5±55.0 °C(Predicted)

Density 

1.059±0.06 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

water: 1 mg/mL

form 

solid

pka

13.43±0.46(Predicted)

color 

white

Water Solubility 

water: 1mg/mL

Sequence

Ac-Leu-Val-{Lys-Aldehyde}

Safety Information

WGK Germany 

WGK 1

Storage Class

11 - Combustible Solids

AC-LEU-VAL-LYS-ALDEHYDE Usage And Synthesis

Uses

Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].

Biological Activity

Cell permeable: no', 'Primary Target
cathepsin B', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 4 nM against cathepsin B

IC 50

Cathepsin B: 4 nM (IC₅₀)

References

[1] McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. DOI:10.1021/jm00060a016
[2] Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702. DOI:10.1371/journal.pone.0075702

AC-LEU-VAL-LYS-ALDEHYDE(147600-40-6)Related Product Information

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