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ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Standard Substance >  (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

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(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Basic information

Product Name:
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Synonyms:
  • F 2207
  • IXEL
  • (1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE
  • (1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIMETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE
  • Milnacipran hydrochloride solution
  • F 2207, Midalcipran, Toledomin, (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride
  • rel-2α*-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1α*-carboxamide·hydrochloride
  • rac Milnacipran Hydrochloride
CAS:
101152-94-7
MF:
C15H23ClN2O
MW:
282.81
EINECS:
620-477-4
Product Categories:
  • NEGGRAM
  • Amines
  • Chiral Reagents
  • Antibiotic Explorer
  • Intermediates & Fine Chemicals
  • Aromatics
  • Pharmaceuticals
Mol File:
101152-94-7.mol
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(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Chemical Properties

Melting point:
179-1810C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: 19 mg/mL
form 
solid
color 
white
Merck 
14,6194
CAS DataBase Reference
101152-94-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
7-16-36/37-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
GZ1014010
HazardClass 
6.1
PackingGroup 
III
HS Code 
29242990
Toxicity
LD50 orally in mice: 237 mg/kg (Bonnaud)

MSDS

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(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

antibacterial

Uses

Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.

Definition

ChEBI: Milnacipran hydrochloride is a member of acetamides.

General Description

Milnacipran, sold under the brand names Savella?, Ixel?, Dalcipran?, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin.

Biological Activity

Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo .

Biochem/physiol Actions

Serotonin and norepinephrine reuptake inhibitor (SNRI)

storage

+4°C

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochlorideSupplier

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