Milnacipran Hydrochloride Chemical Properties

Melting point:

179-1810C

Flash point:

9℃

storage temp. 

2-8°C

solubility 

H₂O: 19 mg/mL

form 

solid

color 

white

Water Solubility 

H2O: 19mg/mL

Merck 

14,6194

InChI

InChI=1/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/s3

InChIKey

XNCDYJFPRPDERF-DPKVYHSMNA-N

SMILES

[C@@]1(C(=O)N(CC)CC)(C[C@H]1CN)C1C=CC=CC=1.Cl |&1:0,9,r|

CAS DataBase Reference

101152-94-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T,F

Risk Statements 

22-39/23/24/25-23/24/25-11

Safety Statements 

7-16-36/37-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

GZ1014010

HazardClass 

6.1

PackingGroup 

III

HS Code 

29242990

Toxicity

LD50 orally in mice: 237 mg/kg (Bonnaud)

MSDS

• Language:English Provider:SigmaAldrich

Milnacipran Hydrochloride Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

Milnacipran Hydrochloride is an antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.

Definition

ChEBI: Milnacipran hydrochloride is a member of acetamides.

General Description

Milnacipran Hydrochloride, sold under the brand names Savella, Ixel, Dalcipran, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin.

Biological Activity

Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo .

Biochem/physiol Actions

Serotonin and norepinephrine reuptake inhibitor (SNRI)

storage

+4°C

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