Pheophorbide A Chemical Properties

Melting point:

191-195 °C

Boiling point:

1019.0±65.0 °C(Predicted)

Density 

1.282±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO: soluble0.5mg/mL, clear (warmed)

form 

Solid

color 

blue, to dark brown to black

Stability:

Light Sensitive

EPA Substance Registry System

3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6)

Pheophorbide A Usage And Synthesis

Uses

Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.

Uses

Pheophorbide-a has been used as a photosensitizer:

• for the photodynamic therapy (PDT) in oral cancer cell lines
• to test its effect on inducing oxidative stress and death in L. amazonensis
• to test its effect on the viability of HeLa cells

Definition

ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).

Biochem/physiol Actions

Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.

Enzyme inhibitor

This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.

Pheophorbide A(15664-29-6)Related Product Information

• Ethyl pyruvate
• Ethyl acrylate
• ISOXADIFEN-ETHYL
• Ethyl acetate
• Ethanol
• Ethylparaben
• Ethyl formate
• Ethyl cyanoacetate
• Methyl pheophorbide b
• Methyl pheophorbide a
• Sodium pheophorbide a
• PHEOPHYTIN A
• 1-(4-Methyl-1H-pyrrol-3-yl)ethanone
• PHEOPHYTIN B
• Pheophorbide A
• vanadyl pheophorbide complex
• pheophorbide b
• N-(2-methylethyl)pheophorbide