Pheophorbide A
- Product Name
- Pheophorbide A
- CAS No.
- 15664-29-6
- Chemical Name
- Pheophorbide A
- Synonyms
- PHEOPHORBIDE A;Phaeophorbide A;Pheophorbide A (>13-Epi-phaeophorbide-a;Chlorophyll Impurity 2;pheophorbide a AldrichCPR;Demagnesia chloric acid -a;Pheophorbide a (mixture of diastereomers);[3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo;Pheophorbide A (>80%) (mixture of diastereomers)
- CBNumber
- CB4426628
- Molecular Formula
- C35H36N4O5
- Formula Weight
- 592.7
- MOL File
- 15664-29-6.mol
Pheophorbide A Property
- Melting point:
- 191-195 °C
- Boiling point:
- 1019.0±65.0 °C(Predicted)
- Density
- 1.282±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: soluble0.5mg/mL, clear (warmed)
- form
- Solid
- color
- blue, to dark brown to black
- Stability:
- Light Sensitive
- EPA Substance Registry System
- 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1218
- Product name
- Pheophorbide-a
- Purity
- ≥90% (HPLC)
- Packaging
- 10MG
- Price
- $54.2
- Updated
- 2023/06/20
- Product number
- 16072
- Product name
- Pheophorbide a
- Purity
- ≥90% (mixture of diastereomers)
- Packaging
- 25mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 16072
- Product name
- Pheophorbide a
- Purity
- ≥90% (mixture of diastereomers)
- Packaging
- 50mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 16072
- Product name
- Pheophorbide a
- Purity
- ≥90% (mixture of diastereomers)
- Packaging
- 100mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- P998428
- Product name
- PheophorbideA(>80%)(mixtureofdiastereomers)
- Packaging
- 50mg
- Price
- $520
- Updated
- 2021/12/16
Pheophorbide A Chemical Properties,Usage,Production
Uses
Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.
Uses
Pheophorbide-a has been used as a photosensitizer:
- for the photodynamic therapy (PDT) in oral cancer cell lines
- to test its effect on inducing oxidative stress and death in L. amazonensis
- to test its effect on the viability of HeLa cells
Definition
ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).
Biochem/physiol Actions
Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.
Enzyme inhibitor
This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.
Pheophorbide A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pheophorbide A manufacturers
- Product
- Pheophorbide A 15664-29-6
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-15