ChemicalBook > CAS DataBase List > Pheophorbide A

Pheophorbide A

Product Name
Pheophorbide A
CAS No.
15664-29-6
Chemical Name
Pheophorbide A
Synonyms
PHEOPHORBIDE A;Phaeophorbide A;Pheophorbide A (>13-Epi-phaeophorbide-a;Chlorophyll Impurity 2;pheophorbide a AldrichCPR;Demagnesia chloric acid -a;Pheophorbide a (mixture of diastereomers);[3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo;Pheophorbide A (>80%) (mixture of diastereomers)
CBNumber
CB4426628
Molecular Formula
C35H36N4O5
Formula Weight
592.7
MOL File
15664-29-6.mol
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Pheophorbide A Property

Melting point:
191-195 °C
Boiling point:
1019.0±65.0 °C(Predicted)
Density 
1.282±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble0.5mg/mL, clear (warmed)
form 
Solid
color 
blue, to dark brown to black
Stability:
Light Sensitive
EPA Substance Registry System
3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1218
Product name
Pheophorbide-a
Purity
≥90% (HPLC)
Packaging
10MG
Price
$54.2
Updated
2023/06/20
Cayman Chemical
Product number
16072
Product name
Pheophorbide a
Purity
≥90% (mixture of diastereomers)
Packaging
25mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
16072
Product name
Pheophorbide a
Purity
≥90% (mixture of diastereomers)
Packaging
50mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
16072
Product name
Pheophorbide a
Purity
≥90% (mixture of diastereomers)
Packaging
100mg
Price
$241
Updated
2024/03/01
TRC
Product number
P998428
Product name
PheophorbideA(>80%)(mixtureofdiastereomers)
Packaging
50mg
Price
$520
Updated
2021/12/16
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Pheophorbide A Chemical Properties,Usage,Production

Uses

Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.

Uses

Pheophorbide-a has been used as a photosensitizer:

  • for the photodynamic therapy (PDT) in oral cancer cell lines
  • to test its effect on inducing oxidative stress and death in L. amazonensis
  • to test its effect on the viability of HeLa cells

Definition

ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).

Biochem/physiol Actions

Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.

Enzyme inhibitor

This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.

Pheophorbide A Preparation Products And Raw materials

Raw materials

Preparation Products

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Pheophorbide A Suppliers

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View Lastest Price from Pheophorbide A manufacturers

Career Henan Chemical Co
Product
Pheophorbide A 15664-29-6
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-15

15664-29-6, Pheophorbide ARelated Search:

Ethyl pyruvate Ethyl acrylate ISOXADIFEN-ETHYL Ethyl acetate Ethanol Ethylparaben Ethyl formate Ethyl cyanoacetate Methyl pheophorbide b Methyl pheophorbide a Sodium pheophorbide a PHEOPHYTIN A 1-(4-Methyl-1H-pyrrol-3-yl)ethanone PHEOPHYTIN B Pheophorbide A vanadyl pheophorbide complex pheophorbide b N-(2-methylethyl)pheophorbide

  • PHEOPHORBIDE A
  • [3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo
  • 3-phorbinepropanoicacid,9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tet
  • [3S-(3alpha,4beta,21beta)]-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbine-3-propionic acid
  • (3S,4S)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid
  • 13-Epi-phaeophorbide-a
  • 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S)-
  • Inchi=1/C35H36N4o5/C1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/H8,12-14,17,21,31,36,39H,1,9-11H2,2-7H3,(H,40,41)/B22-12-,23-13-,24-12-,25-14-,26-13-,27-14-
  • Rel-3-[(3R,4R)-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbin-3-yl]propanoic acid
  • pheophorbide a AldrichCPR
  • Phaeophorbide A
  • Pheophorbide a (mixture of diastereomers)
  • Demagnesia chloric acid -a
  • Chlorophyll Impurity 2
  • Pheophorbide A (&gt
  • 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)-
  • Pheophorbide A (>80%) (mixture of diastereomers)
  • 15664-29-6
  • C35H36N4O5
  • Natural Porphyrins and Derivitives
  • Porphyrins
  • Elisa Kit-plant ELISA Kit