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Calcium 2-oxoglutarate

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Calcium 2-oxoglutarate Basic information

Product Name:
Calcium 2-oxoglutarate
Synonyms:
  • ALPHA-KETOGLUTARATE CALCIUM MONOHYDRATE
  • A-KETOGLUTARIC ACID, CALCIUM SALT, MONOHYDRATE
  • Calcium 2-oxoglutarate
  • Pentanedioic Acid ,2-oxo-,Calcium Salt
  • α-Ketoglutaric acid calcium salt
  • 2-Oxopentanedioic acid calcium salt
  • Calcium 2-oxopentanedioate
  • Ca-ketoglutarate
CAS:
71686-01-6
MF:
C5H8CaO5
MW:
188.19
EINECS:
275-843-2
Mol File:
71686-01-6.mol
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Calcium 2-oxoglutarate Chemical Properties

Melting point:
>300°C (not melting)
storage temp. 
-20°C, Hygroscopic
solubility 
Aqueous Acid (Slightly), Water (Slightly, Heated, Sonicated)
form 
Solid
color 
White to Off-White
Water Solubility 
Water: Insoluble
Stability:
Hygroscopic
InChI
InChI=1S/C5H6O5.Ca.2H/c6-3(5(9)10)1-2-4(7)8;;;/h1-2H2,(H,7,8)(H,9,10);;;
InChIKey
YWFUOMFSJDJVPT-UHFFFAOYSA-N
SMILES
C(=O)(C(=O)O)CCC(=O)O.[Ca]
CAS DataBase Reference
71686-01-6(CAS DataBase Reference)
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Calcium 2-oxoglutarate Usage And Synthesis

Description

Calcium 2-oxoglutarate is a reversible tyrosinase inhibitor, an intermediate in the production of ATP or GTP in the Krebs cycle, and a major carbon skeleton for nitrogen assimilation reactions. It has a variety of biological roles and can be used as a precursor for the synthesis of glutamate, an enzyme involved in the synthesis of amino acids and fatty acids, involved in the transcriptional regulation of cells and influencing plant metabolism, among other roles. Recent studies have demonstrated that mitochondria-mediated calcium 2-oxoglutarate in the rat heart is capable of controlling the formation of aspartic acid.

Uses

Calcium 2-Oxoglutarate helps stabilie redox homeostasis and helps improve arterial elasticity.

Application

Calcium 2-oxoglutarate is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle.

Biological Activity

Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. It also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM).

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