2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties

Melting point:

-20°C

Boiling point:

104°C

Density 

1,47 g/cm³

refractive index 

1.3860-1.3900

Flash point:

28°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

clear liquid

pka

-5.28±0.20(Predicted)

color 

Colorless to Light yellow to Light orange

InChI

InChI=1S/C6H2F5N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H

InChIKey

XIFCGIKPAAZFFS-UHFFFAOYSA-N

SMILES

C1(F)=NC=C(C(F)(F)F)C=C1F

CAS DataBase Reference

89402-42-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

10-36-25

Safety Statements 

16-45-26

RIDADR 

1993

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

2933399990

2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Usage And Synthesis

Description

2,3-Difluoro-5-(trifluoromethyl)pyridine is a useful research chemical.

Uses

2,3-Difluoro-5-(trifluoroMethyl)pyridine is a heterocyclic compound and can be used as a pharmaceutical intermediate.

Synthesis

The general procedure for the synthesis of 2,3-dichloro-5-trifluoromethylpyridine from 2,3-dichloro-5-trifluoromethylpyridine is as follows: 1500 mL of DMSO, 363 g of cesium fluoride, and 8 g of potassium carbonate were added to a 5000 mL reaction flask and heated in an oil bath. Concentrate and cool 600 mL of DMSO under reduced pressure to below 80 °C. Under nitrogen protection, 318 g (1.58 mol) of 2,3-dichloro-5-trifluoromethylpyridine was added to the reaction system and the reaction was carried out at about 110 °C for 48 hours. After completion of the reaction, 600 mL of water was added to the yellow liquid for liquid-liquid separation. The organic phase was dried with anhydrous magnesium sulfate and filtered to give a crude product of 188 g. The 100-102 °C fractions were collected by distillation to give 139 g of 2,3-difluoro-5-trifluoromethylpyridine in 47.6% yield.

References

[1] Patent: CN104628679, 2018, B. Location in patent: Paragraph 0061; 0064; 0065
[2] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 6; 9

2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE(89402-42-6)Related Product Information

• 2-Cyano-3,5-difluoropyridine
• 3-Chloro-2-fluorobenzotrifluoride
• 2-Amino-3-fluoro-5-(trifluoromethyl)pyridine
• 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
• 2,3-DIFLUOROBENZOTRIFLUORIDE
• 2-AMINO-3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PYRIDINE
• 3,4-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
• 2-AMINO-3,6-DIFLUORO-4-(TRIFLUOROMETHYL)PYRIDINE
• 3,5-Difluoro-2-(trifluoromethyl)pyridine
• 2,3-Difluoro-6-(trifluoromethyl)pyridine
• 3,6-Difluoro-2-(trifluoromethyl)pyridine
• 2-Fluoro-5-trifluoromethylpyridine
• 2-Fluoro-5-methylpyridine
• 3-Fluoro-5-(trifluoromethyl)pyridine-2-carboxylic acid
• 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE