RGX-104 free Acid
RGX-104 free Acid Basic information
- Product Name:
- RGX-104 free Acid
- Synonyms:
-
- RGX-104 free Acid
- 610318-54-2 (FREE FORM) 610318-03-1 (HCL)
- RGX-104 (free form)
- SB742881
- Benzeneacetic acid, 3-[(3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]butoxy]-
- RGX-104freeAcid/SB742881
- Abequolixron (RGX-104)
- (R)-2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butoxy)phenyl)acetic acid
- CAS:
- 610318-54-2
- MF:
- C34H33ClF3NO3
- MW:
- 596.08
- Mol File:
- 610318-54-2.mol
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RGX-104 free Acid Chemical Properties
- Boiling point:
- 677.1±55.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO:100.0(Max Conc. mg/mL);167.76(Max Conc. mM)
- form
- Solid
- pka
- 4.19±0.10(Predicted)
- color
- White to off-white
- InChIKey
- ZLJZDYOBXVOTSA-XMMPIXPASA-N
- SMILES
- C1(CC(O)=O)=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C2=CC=CC=C2)C2=CC=CC=C2)C)=C1
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RGX-104 free Acid Usage And Synthesis
Uses
RGX-104 is combination of a liver X receptor β agonist and GITR modulator for treatment of cancer.Liver X receptor beta agonist.
in vivo
Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity[1].
| Animal Model: | NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells[1]. |
| Dosage: | 100 mg/kg. |
| Administration: | Oral administration daily for about 60 days. |
| Result: | Robustly suppressed tumor growth and progression. |
RGX-104 free AcidSupplier
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