6-NITROVERATRYL CHLOROFORMATE Chemical Properties

Melting point:

125 °C (dec.)(lit.)

Boiling point:

396.4±42.0 °C(Predicted)

Density 

1.399±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

solid

color 

Pale yellow

Water Solubility 

Soluble in methanol, acetone. Reacts with water.

Sensitive 

Moisture & Light Sensitive

BRN 

2389168

Safety Information

Hazard Codes 

C

Risk Statements 

34-37

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

10-21

HazardClass 

8

PackingGroup 

III

HS Code 

2918999090

MSDS

• Language:English Provider:SigmaAldrich

6-NITROVERATRYL CHLOROFORMATE Usage And Synthesis

Uses

4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

Uses

4,5-Dimethoxy-2-nitrobenzyl chloroformate (NVOC-Cl) is a photolabile protecting reagent, commonly used in peptide or nucleotide synthesis to protect amines and hydroxyl groups. General applications are:

• Preparation of inactive, caged protein conjugates which can be activated by irradiating near-ultraviolet light.
• Solid-phase synthesis of base-sensitive S-acylthioethyl (SATE)-prooligonucleotides.
• Modification of surface properties by introducing photocleavable NVOC moiety into chitosan to control cell attachment.

6-NITROVERATRYL CHLOROFORMATE(42855-00-5)Related Product Information

• 4-METHOXY-2-NITROBENZYL ALCOHOL
• 6-NITROVERATRYL CHLOROFORMATE
• 4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL
• 3,4-Dimethoxyaniline hydrochloride
• Ethyl chloroformate
• 4,5-DIMETHOXY-2-METHYLANILINE
• 5-HYDROXY-2-NITROBENZYL ALCOHOL
• Benzyl chloromethyl ether
• 5-Methoxy-2-nitrobenzyl alcohol
• Benzyl chloroformate
• 2-Methyl-4-methoxyaniline(HCl)
• 4,5-DIMETHOXY-2-NITROTOLUENE