IGF-I (24-41)
IGF-I (24-41) Basic information
- Product Name:
- IGF-I (24-41)
- Synonyms:
-
- INSULIN-LIKE GROWTH FACTOR I FRAGMENT 24-41, HUMAN
- INSULIN-LIKE GROWTH FACTOR I (24-41)
- IGF-I FRAG 24-41 HUMAN
- IGF-I (24-41)
- H-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-
- H-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-OH
- H2N-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-OH
- TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR
- CAS:
- 135861-49-3
- MF:
- C88H133N27O28
- MW:
- 2017.16
- Mol File:
- 135861-49-3.mol
IGF-I (24-41) Chemical Properties
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- -15°C
- form
- Solid
- color
- White to off-white
- Sequence
- Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr
IGF-I (24-41) Usage And Synthesis
Uses
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development[1][2][3].
in vivo
IGF-I (24-41) (ICV; 200 ng dose; 2 μL; postnatal days 2, 4, and 7) regulates somatic growth and behavioral development[2].
| Animal Model: | Mice of an outbred Swiss-derived strain (CD-l) weighing 30-33g (virgin males) or 28-30g (nulliparous females)[2] |
| Dosage: | 200 ng dose; 2 μL |
| Administration: | ICV; postnatal days (PND) 2, 4, and 7 |
| Result: | Increased the rate of ultrasonic calls of the pups measured on PND8. |
References
[1] Puche JE, et al. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012 Nov 14;10:224. DOI:10.1186/1479-5876-10-224
[2] D Santucci, et al. IGF-I and IGF-I24-41 but not IGF-I57-70 affect somatic and neurobehavioral development of newborn male mice. Brain Res Bull. 1994;35(4):367-71. DOI:10.1016/0361-9230(94)90115-5
[3] Dan Meng, et al. Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radic Biol Med. 2007 Jun 1;42(11):1651-60. DOI:10.1016/j.freeradbiomed.2007.01.037
IGF-I (24-41)Supplier
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IGF-I (24-41)(135861-49-3)Related Product Information
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- ([125I]-TYR)-IGF-I (24-41)
- INSULIN-LIKEGROWTHFACTORI(IGF-I),24-41,RABBITANTI-HUMAN:IH
- INSULIN-LIKEGROWTHFACTORI(IGF-I),24-41,RABBITANTI-HUMAN:RIA
- ANTI-IGF-I (24-41)
- Insulin-Like Growth Factor I (IGF1) (24-41)
- Insulin-Like Growth Factor I (IGF-I), 24-41, Rabbit anti-Human, IF Kit
- IGF-I (24-41)
- H-GLY-GLN-GLY-OH
- AC-THR-OH
- H-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-OH
- H-ALA-ALA-PRO-ALA-ALA-OH
- GLYCYL-L-THREONINE
- H-GLN-ALA-OH
- H-GLN-GLY-OH
- H-ALA-THR-OH