Basic information Safety Supplier Related

MPP+ IODIDE

Basic information Safety Supplier Related

MPP+ IODIDE Basic information

Product Name:
MPP+ IODIDE
Synonyms:
  • 1-Methyl-4-phenylpyridin-1-iuM iodide
  • N-Methyl-4-phenylpyridinium iodide
  • Pyridinium, 1-methyl-4-phenyl-, iodide
  • MPP+ iodide,1-Methyl-4-phenylpyridinium iodide
  • 1-methyl-4-phenyl-pyridiniuiodide
  • MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX
  • 4-phenylpyridin-1-ium iodide
  • MPP+ IODIDE ISO 9001:2015 REACH
CAS:
36913-39-0
MF:
C12H12IN
MW:
297.13485
Product Categories:
  • Aromatics
  • Heterocycles
  • Mutagenesis Research Chemicals
  • Neurochemicals
Mol File:
36913-39-0.mol
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MPP+ IODIDE Chemical Properties

Melting point:
166-168 °C
storage temp. 
desiccated
solubility 
0.1 M HCl: soluble
form 
solid
color 
yellow
InChIKey
RFDFRDXIIKROAI-UHFFFAOYSA-M
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25-36/37/38-25
Safety Statements 
26-36-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
UU6580000
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MPP+ IODIDE Usage And Synthesis

Uses

MPP+ iodide is an active metabolite of the dopaminergic neurotoxin MPTP.

Uses

Dopaminergic neurotoxin; a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties.

General Description

1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Biochem/physiol Actions

MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

MPP+ IODIDESupplier

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