MPP+ IODIDE Chemical Properties

Melting point:

166-168 °C

storage temp. 

desiccated

solubility 

0.1 M HCl: soluble

form 

solid

color 

yellow

Water Solubility 

H2O: 10mg/mL, clear

InChI

InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1

InChIKey

RFDFRDXIIKROAI-UHFFFAOYSA-M

SMILES

C1(C=C[N+](C)=CC=1)C1=CC=CC=C1.[I-]

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-36/37/38-25

Safety Statements 

26-36-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

UU6580000

MPP+ IODIDE Usage And Synthesis

Uses

MPP+ iodide is an active metabolite of the dopaminergic neurotoxin MPTP.

Uses

Dopaminergic neurotoxin; a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties.

General Description

1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Biochem/physiol Actions

MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

MPP+ IODIDE(36913-39-0)Related Product Information

• 2-Phenylpyridine
• Pyridine
• Pyridinium tribromide
• 4-Phenylpyridine
• 4-PHENYL-1-PROPYLPYRIDINIUM IODIDE, 97
• 1-(METHYL-D3)-4-PHENYLPYRIDINIUM IODIDE
• MPP+ IODIDE
• METHYL-4-PHENYLPYRIDINIUM IODIDE, 1-, [METHYL-3H]
• METHYL-4-PHENYLPYRIDINIUM IODIDE, 1-, [METHYL-14C]