Triphenylethylene Chemical Properties

Melting point:

69-71 °C (lit.)

Boiling point:

219-221°C 14mm

Density 

1.0373

refractive index 

1.6292

Flash point:

219-221°C/14mm

storage temp. 

Store below +30°C.

form 

powder

color 

White

BRN 

1867462

CAS DataBase Reference

58-72-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,1',1''-(1-ethenyl-2-ylidene)tris-(58-72-0)

EPA Substance Registry System

Triphenylethylene (58-72-0)

Safety Information

Hazard Codes 

Xn,N,Xi

Risk Statements 

22-36-50/53

Safety Statements 

26-36/37-60-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

RTECS 

KX4920000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29029080

MSDS

• Language:English Provider:Triphenylethylene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Triphenylethylene Usage And Synthesis

Chemical Properties

White to slightly beige powder

Uses

Triphenylethylene is used in preparation of Esterase activated aggregation-induced luminescent anticancer prodrug.

Definition

ChEBI: Triphenylethylene is a stilbenoid. It is the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 82, 1956 DOI: 10.1021/ja01582a025
Organic Syntheses, Coll. Vol. 2, p. 606, 1943
Tetrahedron Letters, 14, p. 4193, 1973

Safety Profile

Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Triphenylethylene(58-72-0)Related Product Information

• 2-Phenyl-1-propene
• Styrene
• Bianthrone
• Tamoxifen
• TRIPHENYLACRYLONITRILE
• CHLOROTRIANISENE
• 1-bromo-1,2,2-triphenylethylene,2-BROMO-1,1,2-TRIPHENYLETHYLENE,1-bromo-1,2,2-triphenylethylene,2-BROMO-1,1,2-TRIPHENYLETHYLENE
• TETRAPHENYLETHYLENE
• 2,3-DIPHENYL-1-INDENONE
• NAPHTHOCHROME GREEN
• Tristyrylphenol ethoxylates
• (R)-1,1,2-Triphenylethylene glycol,(2R)-1,1,2-Triphenylethylene glycol,(2R)-1,1,2-Triphenylethylene glycol,(R)-1,1,2-Triphenylethylene glycol
• (S)-(-)-TRIPHENYLETHYLENE GLYCOL,(S)-(-)-TRIPHENYLETHYLENE GLYCOL,(2S)-1,1,2-Triphenylethylene glycol,(2S)-1,1,2-Triphenylethylene glycol
• 9-BENZHYDRYLIDENE-10-ANTHRONE
• 4,4'-DIMETHYLBIANTHRONE
• 9-BENZYLIDENEFLUORENE
• 6-BROMO-4-METHYL-1-PHENYLANTHRAPYRIDONE
• (ALPHA,GAMMA-BISDIPHENYLENE-BETA-PHENYLALLYL), FREE RADICAL