ETHYL METHANESULFONYLACETATE Chemical Properties

Boiling point:

111-113 °C0.2 mm Hg(lit.)

Density 

1.234 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.456(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

liquid

color 

Yellow

Specific Gravity

1.26

BRN 

1771631

InChI

InChI=1S/C5H10O4S/c1-3-9-5(6)4-10(2,7)8/h3-4H2,1-2H3

InChIKey

OCCWQCYBCZADCE-UHFFFAOYSA-N

SMILES

C(OCC)(=O)CS(C)(=O)=O

CAS DataBase Reference

4455-15-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

23-24/25-37-26

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29309090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

ETHYL METHANESULFONYLACETATE Usage And Synthesis

Chemical Properties

Colorless to yellow liquid

Synthesis

b) Preparation of ethyl methylsulfonylacetate To a solution of ethyl methylsulfanylacetate (Example 61a, 73.4 g, 0.547 mol) in dichloromethane (1000 mL) was added 3-chloroperoxybenzoic acid (m-CPBA, 217 g, 1.094 mol) in batches, and the temperature of the reaction was controlled to be less than 10 °C. After addition, the reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the solid was removed by filtration and the filtrate was neutralized with potassium carbonate to pH=7. The organic layer was separated, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give ethyl methanesulfonyl acetate (90 g, 100% yield) as a solid.LC-MS m/e 167 (MH+).

References

[1] Patent: US2006/4046, 2006, A1. Location in patent: Page/Page column 44
[2] Journal of Heterocyclic Chemistry, 1979, vol. 16, p. 1605 - 1610

ETHYL METHANESULFONYLACETATE(4455-15-6)Related Product Information

• ISOPROPYL METHANESULFONATE
• N-Methyl methanesulfonamide
• Methyl methanesulfonate
• Ethyl methanesulfonate
• ETHYL METHANESULFONYLACETATE
• ETHYL 2-[(4-CHLOROPHENYL)SULPHONYL]ACETATE
• PHENYLSULFONYLACETIC ACID ETHYL ESTER
• ETHYL 2-[(4-METHYLPHENYL)SULFONYL]ACETATE
• TERT-BUTYL 2-[(4-CHLOROPHENYL)SULFONYL]-2-METHYLPROPANOATE
• 1-ETHOXYCARBONYL-1-TOSYLMETHYL ISOCYANIDE
• ETHYL-A-(4-ACETAMIDOPHENYLSULFONYL)ACETATE
• ETHYL 1-(4-METHOXYBENZYL)-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE
• ETHYL 2-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]SULFONYL)PROPANOATE
• ETHYL 4-[(4-METHOXYPHENYL)SULFONYL]-1-(4-METHYLBENZYL)-4-PIPERIDINECARBOXYLATE
• ETHYL 3-((4-ETHOXYPHENYL)AMINO)-2-((4-METHYLPHENYL)SULFONYL)PROP-2-ENOATE
• ETHYL 1-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE
• ETHYL 2-[(4-METHYL-1,2,3-THIADIAZOL-5-YL)SULFONYL]PROPANOATE
• ETHYL 2-[(4-METHOXYPHENYL)SULFONYL]ACETATE