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MINAPRINE DIHYDROCHLORIDE

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MINAPRINE DIHYDROCHLORIDE Basic information

Product Name:
MINAPRINE DIHYDROCHLORIDE
Synonyms:
  • n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamin
  • n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
  • minaprin
  • Minaprin diHCl
  • N-(4-Methyl-6-phenylpyridazin-3-yl)-4-morpholineethanamine
  • TS-370
  • N-[4-METHYL-6-PHENYL-3-PYRIDAZINYL]-4-MORPHOLINEETHANAMINE DIHYDROCHLORIDE
  • MINAPRIN DIHYDROCHLORIDE
CAS:
25905-77-5
MF:
C17H22N4O
MW:
298.38
EINECS:
247-329-8
Product Categories:
  • Active Pharmaceutical Ingredients
  • NAMENDA
Mol File:
25905-77-5.mol
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MINAPRINE DIHYDROCHLORIDE Chemical Properties

Melting point:
122°
Boiling point:
531.2±50.0 °C(Predicted)
Density 
1.156±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 35 mg/mL (117.30 mM)
pka
6.80±0.10(Predicted)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
QE3477830

MSDS

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MINAPRINE DIHYDROCHLORIDE Usage And Synthesis

Originator

Cantor,Clin Midy,France,1979

Uses

Minaprine is a central nervous system (CNS) drug through the use of analog synthesis and CYP2D6 enzyme kinetic analyses.

Uses

muscle relaxant (skeletal)

Definition

ChEBI: Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug.

Manufacturing Process

(a) Preparation of the free base: A mixture comprising 0.1 mol (20.4 g) of 3-chloro-4-methyl-6-phenylpyridazine and 0.2 mol (26.2 g) of N-(2-aminoethyl)-morpholine in 100 ml of n-butanol, with a pinch of copper powder, was heatedunder reflux for 12 hours. At the end of this time, the hot solution was pouredinto 200 ml of cold water. The resulting mixture was filtered through asintered glass filter and the precipitate washed with ether. The filtrate and theether washings were placed in a separating funnel and extracted with two 150ml portions of ether. The ethereal layer was then extracted with about 250 mlof N sulfuric acid.
The acid solution was made alkaline with a 10% aqueous solution of sodiumcarbonate, and left to crystallize overnight.
The solution was filtered, yielding the colorless needles which wererecrystallized from isopropanol. The yield was 15 g (53%).
(b) Preparation of the hydrochloride: The base was dissolved in the smallestamount possible of anhydrous acetone. Double that volume of anhydrousether was added, and a stream of hydrogen chloride gas was passed throughthe solution. The hydrochloride salt obtained was recrystallized from absolutealcohol. The yield after recrystallization was 17 g (90%).

brand name

Cantor (Sanofi).

Therapeutic Function

Antidepressant

MINAPRINE DIHYDROCHLORIDESupplier

LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
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