1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER Chemical Properties

Boiling point:

162.3±23.0 °C(Predicted)

Density 

1.127±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

7.71±0.20(Predicted)

form 

Solid

Appearance

Colorless to light yellow Liquid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER Usage And Synthesis

Synthesis

Stage 1: Synthesis of methyl 1-aminocyclobutanecarboxylate Concentrated H2SO4 (10 ml) was slowly added to a methanol solution (30 ml) containing 1-(tert-butoxycarbonylamino)-cyclobutane-1-carboxylic acid (9.29 mmol, 1 eq.) at 0°C. The reaction mixture was refluxed at 0°C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in distilled water and the pH was adjusted to 8-9 with saturated sodium bicarbonate solution, followed by extraction with ethyl acetate (2 x 200 ml). The combined organic phases were washed sequentially with distilled water (2 x 150 ml) and saturated NaCl solution (2 x 50 ml) and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to afford methyl 1-aminocyclobutanecarboxylate as a white solid in 75% yield.

References

[1] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 34

1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER(215597-35-6)Related Product Information

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